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"This is an important study because it is the first to explicitly test whether ED can predict the future development of CVD beyond a predictive tool called the Framingham risk score," said Andre Araujo, PhD, Director of Epidemiology at NERI and lead researcher of the study. "Although the answer is no, this is not necessarily surprising given how strongly the Framingham risk score is related to CVD," said Araujo. "Our data indicate that ED is as strongly related to the development of CVD as the Framingham risk score."
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Author Affiliations: Creighton Diabetes Center, Omaha, Neb (Dr Rendell); Harbor-University of California, Los Angeles Medical Center, Torrance (Dr Rajfer); Pfizer Central Research, Groton, Conn (Dr Wicker) and Sandwich, England (Dr Smith). A complete list of the members of the Sildenafil Diabetes Study Group appears at the end of this article.
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Hypertension, or high blood pressure, is closely linked to erectile dysfunction. Research shows that between 35 and 58 percent of men with hypertension had ED compared to only 14.1 percent of men with normal pressure.
Conclusion The researchers conclude that erectile dysfunction in diabetes is due to a selective defect in the NO mechanisms within the PVN. This defect is a loss in the synthetic enzyme for the production of NO within the neurons of the PVN. Restoring this synthetic enzyme may have a significant therapeutic value for diabetic patients with ED.
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Potentiates vasodilatory effect of NO, resulting in potentially fatal drop in blood pressure; coadministration with ketoconazole, erythromycin, or cimetidine increases plasma concentrations; coadministration with rifampin decreases plasma levels
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