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Results Two hundred fifty-two patients (94%) completed the study (131/136 in the sildenafil group, 121/132 in the placebo group). By intention-to-treat analysis, at 12 weeks, 74 (56%) of 131 patients in the sildenafil group reported improved erections compared with 13 (10%) of 127 patients in the placebo group (P<.001). The proportion of men with at least 1 successful attempt at sexual intercourse was 61% (71/117) for the sildenafil group vs 22% (25/114) for the placebo group (P<.001). Adverse events related to treatment were reported for 22 (16%) of 136 patients taking sildenafil and 1 (1%) of 132 patients receiving placebo. The most common adverse events were headache (11% sildenafil, 2% placebo), dyspepsia (9% sildenafil, 0% placebo), and respiratory tract disorder (6% sildenafil, 2% placebo), predominantly sinus congestion or drainage. The incidence of cardiovascular adverse events was comparable for both groups (3% sildenafil, 5% placebo).
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Reality: Although the majority of diagnosed ED cases are a result of physical diseases that cause damage to nerves, fibrous tissues, and arteries (such as diabetes, MS, vascular disease, and neurological disease), experts theorize that up to 20 percent of ED cases are due to anxiety, stress, depression, and other psychological factors, according to the National Kidney and Urologic Disease Information Clearinghouse (NIDDK). One of the most common psychological causes of erectile dysfunction is performance anxiety that may result after several failed attempts at intercourse. The anxiety may increase, leading to more failed attempts, ultimately resulting in a cycle of anxiety and sexual failure.
"Pulmonary arterial pressure -- when it is elevated -- is a poor prognostic sign and reducing its levels should be of help," he said. "However, more testing is needed to see if those changes in pulmonary arterial pressure are translated into better clinical outcomes and not into any unwanted side effects."
A recent study of more than 8,000 Australian men between the ages of 16 and 59 found that those who smoked less than a pack a day had a 24 percent increased risk of erectile problems. And, as the number of cigarettes smoked went up, so, too, did the chances of erectile dysfunction. Those men who averaged more than 20 cigarettes a day increased their risk of erectile dysfunction by 39 percent, reported the study, published in the journal Tobacco Control.
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